With the ever growing recent popularity with Metal Gear Solid V: The Phantom Pain, I'd love to see Konami and Fantasy Flight Games to merger up a partnership to bring in the Metal Gear franchise to a living card game. And possibly future enterprises such as board and/or miniature games within the Metal Gear Universe.
There's definitely more than enough material to work with from over the years, and several variants of opponents, alliances and team developments for factions to work as a two (or more) player competitive game. Set-up in locations, from Shadow Moses, the USS Discovery, Afghanistan - Northern Kabul and so forth could give a form of domination over territories type play-style. Tons of different characters could be included in chapters/expansions of the game, and could develop as future expansions are released. An example could be Revolver Ocelot of Metal Gear Solid 3, is a very different character in say Metal Gear Solid 4 and the same could be said about Kaz from Peace Walker to Metal Gear Solid V. Plus lots of options can be used with the tons of special, or "hidden" characters such as Hideo Kojima himself, or the generic soldiers with names like Morpho, Swan, Jaguar, etc.
Include the many vehicles found throughout the series, from standard military jeeps, trucks, tanks and aircraft...to more exotic weapon platforms like the Metal Gears themselves. This can give an heavy combat side of the game, though side missions of espionage and more stealthy operations could be just as important. Stealing development information, extracting VIPs, and locking down desired assets that will help future maneuvers against your opponent. Even assassination missions against important characters, that could change the story as it progresses. You could even recreate crazy situations like MGS3's Time Paradox by killing a Main Character, which would alter the state of the future. But, if you know Metal Gear lore well enough, you'll know it's near impossible to actually kill permanently anyone with more than six lines of dialog for any great lengths of time.
So yeah...I think it'd work out pretty good.
Cheers!