Played my first MH game yesterday in a single-player, four investigator megamix of all the current expansions.
Quick hits: This was my first loss via getting Act III into play, but more interestingly I had one character with a "One of the Thousand" membership and a corruption card who furthermore actually had several cult encounters, several exhibit encounters, one investigator ending up at the SHHitM, another investigator drawing no less than five Innsmouth Look cards at once, and finally failing a vicious vicious new rumor "To Conquer Death" that makes all monsters endless and undead not count towards the monster limit.
Of course the worst part was when Roland Banks was the FP and drew the Mythos card "Rash of Missing Person" or whatever it's called where the first player must pick an investigator to be LitaS. I was playing against Yog-Sothoth and Dunwich Horror. I can't imagine that happening in a real multiplayer game. Ouch.
I really like the effect MH is having on the game, the only downside is that I was using the bureau of investigations and I really didn't use them at all the entire game. Maybe it's just me, but I'm a stingy bastard with my clue tokens.