I'm thinking of running a game based on journeymen wizards from the colleges of magic. So the players each represent one school of magic, while also having non magical careers to best represent their assorted vocations within the college.
Starting off as second career characters and getting steadily more over and super powered, with little regard to the whole "six careers only" malarkey, I'm kinda looking forward to seeing how ludicrous this gets.
Another fun thing is going to be that magic items will start to appear, first a few, then steadily more ludicrously powerful items.
I welcome suggestions for interesting stuff and McGuffins, and I'll be throwing some of my own stuff on here for discussion.