So I just finished my latest game of EH. The Ancient One was Shub Niggurath, and the Investigators were Charlie, Jim, Mark, and Jacqueline.
The first mystery I pulled was Hunting the Thousand, and it occurs to me that it's a fairly random mystery. Since it's based off the toughness of the monsters, it's possible to solve it very quickly or very slowly depending on which monsters you draw, and if you are powerful enough to defeat them. I also had the misfortune of most of my early monsters getting tucked away where I couldn't get to them - Elder Things, Serpent People, a Mummy - so it took a looooong time to resolve. Comparatively Knowledge of the Dark Mother was a breeze. Unfortunately it took so long to complete Hunting the Thousand that by the time I had solved my second mystery, Shub Niggurath awakened. I managed one more turn before losing the game; it just doesn't seem possible to win if the Ancient has awakened unless you have nearly finished the third mystery.
Notably, Charlie received a Blessing. He lost the Blessing to a Warlock, and then received a Curse from spawning Wraith, and then had to lose two Health and two Sanity because he couldn't discard a Blessing. Sometimes the game just feels like it's flipping me off.
I managed to receive a few good Artifacts, but they were inevitably handed to someone who they weren't "for". Mark received a Gate Box for the Gates he had no hope of closing, and a Artifact to aid in the casting of spells he didn't have.
Part of me feels I would be served better if Jacqueline or Charlie had been replaced by a combat oriented investigator, but their utility is too much to just casually dismiss. Getting items without Charlie is much, much more difficult, but he's so very frail. Jacqueline is good for Clue tokens, but she seems to be just crappy enough at everything that she never really rolls well, and it gets irritating at times. Mostly she's great for the western half of the board, but then she gets bogged down.