You realize that 40k is largely a universe where such a 'spirit' can be lost can be lost, correct?
[...]
The only way I can see someone "becoming" untouchable is through some truly arcane, deeply traumatic and irreversible event that permanently cuts you off from the warp, ripping your soul away from you, leaving the dreadful husk behind.
A latent psyker is one who through some means 'bloomed' out into the warp, where once that spirit looked as a tiny human flicker, brightened into the beacon in the immaterium that is a psyker.
And so a latent untouchable would be the exact opposite, who was born with perhaps a tenuous spirit that eventually caved way into the nulling pit that is a pariah.
Edited by FgdsfgThose two obviously discount things like xenotech alterations.
Having your bones replaced by nullrods is quite a sensible 40k thing to do.