I've seen this topic mentioned in numerous threads, but I figured I'd consolidate it into its own discussion for visibility's sake.
I feel there should be some kind of social trade-off for carrying around high-tech weapons like bolters and plasma guns and wearing military armor. This could come in the form of a hit to Subtlety, or it could influence the starting Disposition of NPCs. Similarly, carrying location-appropriate weapons and armor would boost your Subtlety and influence NPC disposition. I believe there is currently a penalty to Subtlety for carrying heavy weapons -- this is a good start, but I think a suit of power armor and an inferno pistol are even more conspicuous.
Note that heavy armor and strong weapons don't always need to have a negative effect on NPC dispositions -- the reaction you receive depends on the personality and station of the NPC. For example, if you approach an Imperial Guard officer looking like a capable warrior, you will likely get more respect than if you look like a street ganger with a laspistol. Conversely, a gang boss will not like characters who draw attention to themselves with fancy gear and will respond better to those who dress discreetly. Maybe a Tech-priest would be impressed by characters who bear numerous cybernetics or carry advanced weapons like ancient plasma guns. It would be nice to see specific guidelines and Subtlety/Disposition bonuses and penalties explained in the rulebook.