This is just a fun little exercise in strategy. I don't think there's one right answer to this situation, but I'm really looking forward to hearing how people would deal with this situation and why they would make the choice they make.
You're playing Sith and have Vader out. Your opponent has Luke with Old Ben's Spirit attached. After he draws, you play Interrogation. In his hand you find Yoda, another Old Ben's Spirit, Lightsaber Deflection, Twi'Lek Loyalist, Dagobah Training Grounds, and Twist of Fate. You will kill Luke with Vader's Reaction after you finish resolving Interrogation.
Which of those cards would you remove with Interrogation?