What I would really like to see is a game based on NBC's Heroes. As far as I can tell, there is nothing out there anywhere (unless it is some cheapo mass market game with a very loose theme pasted on) about this pretty popular TV series.
There are enough characters that a CCG would be a natural fit. But it also seems an adventure type game would work as well. Players could have character specific decks like in Android that reflect their special abilites. Effects could also be countered (like with e haitian) or duplicated (like with Silar and Peter). You could build them up over a few turns on a character sheet as they struggle to understqnd and develop their powers.
FFG seems the perfect company to grab the license, set up the character specific components (including miniatures of course!) and make the rest of the game look and play great.