I kinda liked the discussion which this combo sparked. I have opinions on its merits and place in the game but I'll keep them to myself, as it would derail the purpose of this topic.
Now, I have read that mono Miskatonic (which I agree is not yet tourney ready) has no chance to stop this combo turn 0.
As a thought exercise, I begun to think of a way to stop it with Miskatonic University cards. Turns out there is. In fact, mono Miskatonic has at least two ways to. Most of these methods are statistical and may employ non strictly Miskatonic cards, but rest assured that they are meant for a deck which will be 90 to 100 Miskatonic cards.
1) Night Class -> Natural Philosopher. The Large Man can recover only the topmost event in the discard pile. If you can force another event over it, the combo breaks down. Now, if you put 3x Night Class and 3x Natural Philosopher, while the opponent is allowing you to draw as many cards as you want -including, for instance, Professor Morgan or 3 Rich Widows which will get into play when your Philosophers leave play-, you can force the opponent to discard his whole hand, which means that, if he has at least one other Event card in his starting hand, the combo is broken. By the way, do not forget to grab a Notebook Sketches or two to seal the deal the next turn.
2) Night Class -> Museum Curator. Another statistical method, it allows to fire the Curator thrice. Now, on the top of my head, the Curator could try to find a Notebook Sketches, or a Cursed Skull, or a Khopesh of the Abyss, or an Infernal Obsession (FUN!), or a Seventh House on the Left, or a Bound and Gagged, or a Terrors in the Dark, or a Snow Graves, or, well, do I really need to go on? Remember, this combo allows you to draw as long as you like it, so why not prepare your Peaslee infinite loop meanwhile?