Into BB fluff? Is it following the setting of the video game, the board game or is it isolated?

I never played the video game but have extensively played the board game. What are the differences between both?

Depending on the rules you enable - Zero difference.

Video game has a real time mode as well, but that is best left forgotten.

From the little ive read it sounds isolated ( not a bad thing ) but really who cares , its Blood Bowl...