The cards in this game actually are a great random adventure / encounter generator in themselves. Take the location card dec shuffle it up and draw three random locations. Take the item dec shuffle it up and draw a random item card. Whala you have the setting and goal, add some NPC's ( picking a couple random career cards could do this for you) and some monsters and your good to go. If you want the bad guys connected to a larger organization the same could be done with the nemesis card dec.
Once you have those pieces laid out connecting them should be fairly simple. If you want to get fancy or don't like to wing it add some canned dialog to set the scene and provide the hooks. This system lends itself well to free form games and letting PC's go off on whatever tangent they want. If they flounder at the hooks or can't decide what to do just ratchet up that party tension meter until they get the hint.
My group is getting ready to go from Eye for an Eye to The Gathering Storm, and after reading TGS there are just so many places this adventure can be expanded upon or used as a stepping stone to additional adventures which is what got me thinking of how to easily add in additional content on the fly. Anyone else tried anything like this yet?