I'll probably buy this because the bits seem useful and the Nemesis rules and organisations are intriguing. Oh, and I'm a sucker for 'new-shiny'.
What I find confusing is the constant wailing and gnashing of teeth over everything. Is an RPG ever complete? Yes the wizards and priests could do with expansion and yet to have included higher careers and another 100 spell cards would have served only to see other stuff left out of the box or the price go up even further (which is the other thing lots of people complain about). Mutations? Use the A/C/E to represent them, or modify stats, or whatever - it's not that tricky.
Sorry if I sound like I'm having a go, but honestly, if there isn't a specific rule for something you want to do in the game at the moment, make it up. Isn't RPGing about imagination after all?