As far as I can see from RaW the only way to get a wheeled vehicle to get out of control because of a hit to the tyre is to be either very lucky (and roll righteous fury) or to first reduce all the integrity to zero and then get critical damage.
An Example:
A sniper takes a Called Shot with his long las set to overload mode at a rear wheel of a Viator Desert Crawler (featured in Forgotten Gods). Because he takes the Called Shot he does not get any bonuses from the Accurate weapon trait (no aim action involved). He luckily hits the tyre. He has Mighty Shot and high BS totaling to a damage of 1d0+8 with Pen 3. He rolls a 9 resulting in 17 damage with Pen 3.
Now the Viator starts with AP 14 at the rear and 25 integrity and just gets 6 damage from this rather heavy hit to the tyre. That's it.
To me it somehow feels that a Called Shot to a tyre should have a better chance than that to cause serious problems to the driver. At the least the AP of the tyre should be much lower than the standard AP on the hit facing. And if getting any damage the driver should be forced to roll a Operate-test against getting out of control or something.
What are your thoughts on that?