So, you're an Inquisitor, patrolling this world for heresy/further heresy. As an Inquisitor, you might have access to any data caches on the planet, and you might have information nets/contact networks that can find out almost anything, but what happens when you need to know something about someone "from out of town"? Inquisitors might be detail-oriented, and have memories like a steel trap, but even they can't remember every person they've ever seen, or they haven't maybe ever seen them, before. Say you are investigating a fellow Throne Agent, or maybe a Rogue Trader? Any information about them when not on this planet is, well, not on this planet. How does the Inquisitor get the info they need, the details about who that is, what they believe, what they've been up to?
I suppose this might just be me harping on the 40k verse for not having e-mail, but do they really grab an astroapth, ask him questions pertaining to sensitive matters, wait for him to broadcast, wait for the message to pong it's way across the sector, get translated, someone go find info, repeat, and then have the astropath, or some scribe/servitor take dictation on the possible volumes of sensitive info the other end might be sending? Sit around for a week, to a month, waiting for an Inq ship to bring a data cache? It might help maintain the grimdark feel of the difficulty the Inquisitor's job contains, only barely containing evil, even with all their resources, but how do they make it work? For the Inquisitor whose network goes beyond a single world, maybe even a single solar system, how do they maintain their contacts as a viable advantage?
I had this issue, too, in Rogue Trader, when I wondered if worlds had a few extra astropaths, just because, to send messages, or how did the Rogue Trader keep up with all of his assets, opportunities, and foes? If you were to play Lure of the Expanse, did fate just ham-fistedly deposit you on Footfall in the right time frame for the Fortelling? You, and half a dozen others? Did one of your contacts hear about it, and dispatch an astropathic message, which might take a while, and then you need to warp jump, and system travel, for about a month? With the Rogue Trader so often out on the frontier, starting new colonies, looting old tombs, and mapping the tattered edges of the map, how does the dynasty stay in contact, and how do business opportunities find them? The big difference here, though, is that the Rogue Trader's job might be seen as selfish; a plan to get rich, and be a pirate lord, thinly veiled under service to the Emperor, but the Inquisitor's job is often seen as safeguarding the entire Imperium. In your games that don't only cover one world, with no threads that reach beyond it, how do they handle this sort of thing?