So, I may have discovered the most lethal combination of cards in the game. I'd set up against Yig, drew two preludes and picked one. I figured I'd try the Child of Abhoth prelude, simply because I'd never used it before (each investigator gains an illness condition and 1 clue).
First round, and I fail to shake any of the illnesses. Then the first Mythos card - Food for Worms (ongoing, each investigator gains an illness condition, then on the next reckoning, investigators loses 3 health for each illness condition they have).
In short, the next Mythos card (Wanderlust) has a reckoning. One investigator is already defeated, the rest are left so crippled that over the next three rounds they could do nothing but watch as gates popped up everywhere, while trying to avoid a proto-shoggoth. Doom hits 6 and I have accomplished nothing and the Child of Abhoth epic monster, which I now have no chance of taking down, keeps churning out more illnesses, preventing healing.
Now I'm as much of a masochist as any of us who love this game, but that was ridiculous . It's not often I quit a game so early, but it was effectively over after the first round. I called it in the fifth Mythos phase.