The folks over at Retrozap released a very interesting article that immediately made me think of FFG's awesome Harm Mastery. Obviously Palpatine would have to have some sort of crazy NPC Range Upgrade but check out the link on Retrozap. I think this would make a great canon example.
http://www.retrozap.com/padme-didnt-die-of-a-broken-heart/
Just goes to show that the folks at FFG know what they are doing.
Edited by Gigerstreak