Say a crusade was launched and the Expanse was slowly being turned into a sector as the PC's conquered worlds and brought the light of the God-Emperor to the darkness between stars... How would that change things? Would the local Rogue Traders loose power? Would the Inquisition have more of a leg to stand on? How are things like capitals and governance determined?
Seems like this would make an interesting campaign, or series of campaigns, for a RT dynasty.