It reads that you can discard 4 poison (when it is explored)
I have just thought: if you don't have 4 poison, but you have only 3 poison? Can you active the response or not? Because there is a treachery in CORE that reads: Remove 4 progress tokens from the current quest card. (If there are fewer then 4 progress tokens on the quest, remove all progress tokens from that quest.)
It must be written?
PD: and other question: if you have 4 poison but you are interested in discard only 3 (for example, to avoid the surge of Poisoned by Spiders -see above-), can you do so or you must discard 4 as it reads?