So, this idea has come to me recently, now that I'm learning about the colonial period in America.
Basically, the PCs are hired as guards to protect a new colony heading out to the Wild Space to start a new colony, as it supposedly has some rare minerals. They are just social outcasts, and won't say exactly where they are headed. They are transporting everyone in their own ships, because the path is complicated and requires a lot twists and turns.
It turns out after a solid week of traveling in these large colonial ships (Consisting mainly of Humans, Ithorians, and some Duros, with a few scattered races as protection and random individuals), they have arrived at their destination, a system that is surrounded by nubuli that won't let any astrogation possible.
It turns out at this point that this is actually the Unknown Regions, and these colonists humans people escaping Imperial opression (the Humans tried to help aliens, the Ithorians were trying to preserve nature on industrial planets, and the Duros were just out to get a colony). The captain will apologize that he didn't tell the guards sooner (as there are plenty of them), because if they knew they were going into Unknown Space, the Empire would follow and annialate them. It's too late to go back now, as the hyper lanes have all collapsed. The PCs are now stuck on an unknown planet.
The colonization quickly begins, and the PCs have the opportunity to help (they are offered food and shelter in exchange for aid). If the PCs had Obligation, it's followed them on the ship, by sneaking on and hiding away, or just being a colonist (if they have the obligation to protect a little sister, they went to protect her on the way). Credits are still the main source of currency, and there are thirteen planets under colonization (direct reference to the thirteen colonies).
However, as the colonies progress, and a few weeks pass by with simple jobs like fighting off animals and trading supplies, it is discovered that there are native races to these planets. They resemble large space badgers, and are really just a bunch of murderous pirates. They will mainly attack the settlers, though a few will do trade with them. The PCs now have a new enemy to fight.
This is a tight sector, and the space badgers, known as the Urraka, have primitive ships that can take them between the planets. They will often do raids on the unprepared colonists, who only brought enough guards to see that everyone is relatively safe.
There is now a war going on between the colonists and the Urraka, which pits the PCs in the middle to either bring peace or annihalate the enemy.
I'll keep going on this campaign, but for now this is the basis. Fell free to give me your thoughts!