When the Fluff says that no one has ever made a profit at some endeavor, that it has ruined every Rogue Trader who's tried, and that there is NO WAY that a Rogue Trader should ever be allowed to pull it off, the players just take that as a challenge.
-When the Fluff says that no one has ever made a profit at some endeavor, that it has ruined every Rogue Trader who's tried, and that there is NO WAY that a Rogue Trader should ever be allowed to pull it off, the players convince someone else to do it, and profit off their failure.
-When your players have the chance of being the villains of a Dark Heresy campaign.
-After a ruined Rogue Trader has come back to civilization telling of dead stars in the darkness on the fringe of the galaxy, the first thought of the group is "Hey neat, let's go there."
-The second thought of the group is "Hey, according to physics, collapsed stars can be made up of gold..."
-After a long investigation by the Ordo Xenos where your players have been found innocent despite the fact they are guilty, you can hear the Lord Inquisitor mutter "Forget it Leviticus, it's Footfall..." as he walks away.