There are only a few cards which I feel really tip the balance of this game so far. The biggest culprit of tipping the pendulum in the runner's favor (and if you think the runner is not at an advantage, then I will debate you till I am blue in the face), is the card Magnum Opus.
1 card, and all your credit generating problems are over. The only corp card that compares to opus in terms of clicks invested, and credits returned is a card I'm sure many of you play called melange mining corp. The trouble is, mining corp can be trashed, and opus cannot - unless you impale it on an ichi or the like…
Couple Magnum Opus with cards like Vamp, Crypsis, etc. will give the corp a serious headache - taking credits, credits credits, and vamping the corp is still one of my "favorite", although approaching lame, things to do. Trap protection included
The corp intrinsically, because of this card is going to almost certainly lose the credit war. Asset credit generation will almost certainly fall short in comparison to the runner's, because as stated, corp assets can be trashed. Commercialization is another story, and another post altogether.
If Opus was 10 to install, and 3 MU, I'd still run it. The corp usually splashes, what, 12+ credit generating cards? The runner needs no more than an Opus and 3 test runs.