So the deck is Cthulhu, Miskatonic, Silver Twilight. You have an Atwood Science Hall with Lodge Defenses attached. You use the Lodge Defenses (after you sacrifice a ST character, pay X to return a character cost X or lower to your hand) to play and sacrifice Dedicated Butler (After Dedicated Butler enters play discard a card from your hand or sacrifice dedicated butler) infinitely.
This gives Erasmus Manor (after a character you control leaves play, Erasmus gains CI until the end of the turn) INFINITE COMBAT, INVESTIGATION, AND SKILL.
NOW, during your story phase, you play Misguided Dreams, so all characters must commit to stories.
THEN, you commit Erasmus Manor and Halflings of D'Haz (the loser of the combat struggle must take an additional wound for each combat icon he lost by), and your opponent must commit all of their characters. With infinite combat you kill all of your opponents characters without invulnerability. With infinite investigation and skill you are guaranteed 2 success tokens! Throw in Parallel Universe for more zany fun.
HOW COULD YOU POSSIBLY STOP THIS DEADLY COMBO!?!?!?!