Today I played a 100pt game with Biggs Darklighter with R2D2. The idea was to use Biggs ability to force my opponent to shoot at him (protecting my other ships) and then use R2 to regenerate Biggs' shields.
Vader and Mauler Mithel blew Biggs up before he even got to shoot.
The moral of the story: Even the most seemingly powerful pilots and cards (like R2D2) are fragile. It's a gamble to spend points on upgrades which may not survive long enough to get used.
I think this is even more true at 100 points, where more guns can focus one target in a given turn.