When you pull out your alchemy tiles, be sure you have a set-up tile and 12 alchemy puzzle pieces; unlike other puzzles, missing one, especially a yellow one, can make the puzzle impossible. I've played two close games that were completely ruined because I never realized a yellow piece was underneath all my other puzzle set-up tiles, away from the other alchemy pieces.

Thought I'd share what seems to be an obvious idea, until you are ready to set fire to your board game's alchemy puzzle in frustration.

Meh, even if you go 8/8 on the puzzle, you can still fail it. Only play of Lost in Time and Space so far, end went like this. Kate Winthrop, Alchemy Puzzle, 8/8, rolls a 10. Next turn, 8/8, rolls a 9. I play Panic on her after she takes horror to move her three spaces, thus wasting a turn. She runs back, fourth attempt, 5/8, rolls an 8, fifth try, 8/8, rolls a 10.

Dam said:

Oh, no!

Yeah, just wanted to let players get at least odds of winning. We didn't even get that when I misplaced the yellow piece in the box unwittingly.