So, if I was to wish to run LotE, two questions I would ask. First, is it a good idea to pretend that the other books (Into the Storm, Hostile Acquisitions, and Battlefleet Koronus) don't exist? Without some heavy modifications, many of the cool things in those books aren't drawn upon by you opposition, and being the only group with a battlecruiser, torpedoes, Nova Cannons, and Alternate Career levels smacks of unfair, while twinking each foe to have some of that is a lot of work. Second, is there a suggested "level" where players should be for it? Hadarak Fel has an improved stat block from RT, so some time has passed. What's the expected PC range in LotE? I know that this system doens't like to set things up that way, but I still wonder about it; it helps me to think.
I really like LotE, and if I were to get to sucker some friends into playing Rogue Trader, it's a run I'd like very much to put them through.