Response: After a card is discarded from an opponent's hand, choose 1 character. Until the end of the phase, that character gains or loses an icon of your choice.

So how does with work with Plots like Rule by Decree or Threat From the East? Is each card discarded considered a separate trigger? The proces of discarding cards from hand is not explicitly described in the FAQ; however, I believe it would follow the same precident as drawing cards:

"(1.1) Drawing Multiple Cards When a player draws multiple cards (e.g., by drawing 2 cards during his draw phase, or due to a card effect like that of Insidious Ways (CORE L163), he is considered to be drawing them one at a time, not all at once. This is important for effects that may trigger by a card being drawn."

Although initiating from a single effect, I would think this location would be able to trigger multiple times for these events. Thoughts?

Indeed, each discarded card creates an opportunity. Though it's unlikely (but not impossible) messing around with icons in the plot phase will be much use. If a Baratheon player used For R'hllor in the challenges phase, though…

Indeed Khudzlin - but you're not thinking outside of the box. If revealed during the challenge phase, either by a rookery or Bungled Orders, it would be MOST fun. Especially with one or more A Poisoned Spears in play…

Could be amusing with Narrow escape too. It's a second Viper's rage.

bane2571 said:

(4.12) The Hand
Any reference made to a player’s “hand” refers to that hand as a single entity, and does not refer to any of the individual cards in that hand. Thus, it is possible to discard a “hand” of 0 cards. Further, if you do discard your “hand,” you are not considered to have discarded any of the individual cards that make up that hand (for the purpose of initiating other card effects).
Revealing your hand is not considered revealing any of the individual cards in your hand, and adding a card to a revealed hand is not considered revealing that card.

So discarding your hand for Narrow Escape does not create a number of "after you discard a card from your hand" Response opportunities equal to the number of cards you had in your hand.