I am a fan of Lovecraft and board games. Buying Mansions of Madness was almost not a choice for me. However, I've played the game three times as a Keeper and once as an Investigator and although playing the game was fun and memorable, the setup time, and storage time negated the fun. As Keeper, if at all possible, I set up the game ahead of time, and the first time it took me 1.5 hours to do it (including double checking).
I played it again last night with a couple of people who love board games and role-playing games. The wife brought up something that I've been thinking about board games for a long time now:
This needs to be on a computer. Preferably online with voice chat.
Some will say that board games are best enjoyed face to face, and I agree, but I think that there are those who would enjoy the fun of these games online for many valid reasons.
The biggest problem, of course, is MoM's setup/storage time. Sure, you could spend 3-4 hours and extra money devising systems to speed it up a bit, but come on, that shouldn't be necessary.
Also, if MoM were online, the game could be updated without much difficulty.
Yes, there's a lot of effort involved with doing a project like this for MoM, or other games, but consider this: Just make a virtual tabletop with virtual pieces. Forget the AI. Forget integrated rules. Let the players handle the rules. Just use the computer for setup.
MoM is a great game, but it wasn't meant for the table. Arkham Horror, I'm looking at YOU too.