Just played a solo game of Death Angel. Was doing really well, made it through a teleport with no casualties and still had 4 of my 6 marines going into the final area. But the final area was Genestealer Lair, which put a Brood Lord on an impossibly large swarm. The previous location did not have a door so I could not drop their numbers during travel, then I lost my big damage dealers. The result? The Broodlord spent one turn after another snacking on my Terminators.
I must have a thing for games that knock your teeth out.