This is GM talk! SPOILERS AHEAD! Consider yourself warned.
In my opinion The Black Sepulchre is the worst Dark Heresy supplement published yet. However, it's still usable I think.
The Intro action scene is nice. The setting I found a bit unspectacular though. So I switched to Hive Tarsus, with the manson obviously located at the bottom of the hive. The characters won't arrive in a gunship but will be abseiling about 300m from the "ceiling" (the bottom of the next Hive level). It's dark, warm and moist with the arcane hive machines humming and moving above them. Smelly and possible toxic liquids drip from rusty steel rods. As they go down - at about 200m - they are suddenly hit by wall of icy air. REM: The nobles of Tarsus enjoy freezing temperatures where they can comfortably wear their fur coats. The drops of liquid turn into yellowish snow flakes. From that point onward the scene can pretty much progress as written.
Now. The background story I found unnecessarily convoluted and unconvincing. I'd go for something a bit more straight forward, focusing on the daemon itself rather than on the Maledictor's Hand. The journey to Baraspine, the Guilded Cathedral and the actual Black Sepulchre... just don't feel right. Instead I let the evidence lead the characters straight to the Black Cathedral, or rather: the mansion of the Hekate family. Which is a rather nice haunted house environment. Very usable. Same goes for the secret of the cathedral, which is - let's be honest - an amusing twist. It could easily be located on, say, the eastern fringe of Hive Tarsus. A somewhat deserted area, with a cursed house being close by and all.
The final battle is quite lame. Again I'd go for something rather more direct. Let's imagine the rotting body of the daemon ist buried in the desert sands of Scintilla, just outside the hive. The characters' actions would lead to the re-awakening of the daemon. Very apocalyptic: a gigantic bird like zombie thing with leathery wings rising from the sands, the morning sun glowing blood red behind it. Of course the Acolytes will have the opportunity to blow it to cinders with the Titan's quake cannon.
Of course it's still all a bit rough. Any suggestions ? Different angles ? Better ideas ?
Let's fix this, guys!