My first adventure (if you can call it that) was a little combat exercise that pitted the two acolytes I have as players against a tech priest who had a warp rift he had constructed via heretical research. During the course of that encounter he disappeared into it, as did the players as their only means of escape from the station (the priest's sponsor, a chaos marine, was en route).
Now I have decided to send them to another station, the priest's former hq, where his followers are trying to summon his spirit from the warp into a specially prepared cogitator and they have lured the acolytes as part of a trap. They are travelling back from another mission and are unaware of what's going to happen. Their involvement is deemed necessary because they have been through the portal. Who can think of a means to involve them in a preparatory ritual that won't kill them but will be successful, leaving them to survive and fight against the priest's spirit as it takes over the mechanisms of the station?
