I noticed something while looking through the cards - there are two forms of Gnatanothoa. This by itself is not unusual, there are two forms of several Ancient Ones. But, the ability to have six copies of some kind of Gnatanothoa seems to mesh will with the ability on the Out of the Aeons version which reads:
Action: Reveal another copy of Ghanatothoa from your hand to choose and destroy a non-Ancient One character. Then, shuffle that copy of Ghanatothotoa back into your deck.
So, you can destroy any non-Ancient One character for merely the cost of a card in your hand. There is no domain required, exhaustion, etc... Think of it this way, he basically says that any Gnatothoa card in your card can also be played as a (roughly) a zero cost event to destroy a non-AO character. With six copies in your deck and being shuffled back into the deck after each use, he ought to show up fairly often, and once you get him in place he's hard to kill being an Ancient One with Invulnerability.
So I'm wondering what the veterans think, is it possible to make a decent deck incorporating this? You've still got 44 other cards you can use to run your main strategy, but this provides you with bonus character removal that doesn't rely on wounding. If you did design a deck around this, what other cards would you consider a must-have? I'm thinking that Seeker of Mysteries is a likely prospect to get him into play, and maybe you could look at pairing with another faction that has cost reducers or ways to search for more copies.
Of course you also can still play the Lord of the Volcano version normally as well, who can have a huge number of Combat icons if your hand size is large.
I did a search and couldn't find any posted decks or prior discussion about Ghatanothotoa so I don't know if he's been overlooked or just silently agreed to be not worthwhile.