As a solo player, I love the unpredictable nature of this game. I have about 10 plays under my belt with two wins but it amazes me how unique the games can be even when using the same expansions multiple times in a row.
I played the last two games with the King in Yellow (first time), Dunwich Horror, and Miskatanic expansions. The first game lasted about 20 turns and I never had any reason to even look at the first Act card. I ended up losing during the Ancient One battle. I picked new inspectors and reset the game. This time, the first act was playing after the second mythos came out (I paid a doom token to stop it coming out on inital mythos card draw), and the second act began when The Next Act Begins card showed up on turn 3 and Act 3 came crashing down and bringing the game to an end after another The Next Act Begins card came into play after the sixth round. I just shook my head and took the beating!
Time to reset for another go with a new Ancient One and four new investigators....what will Arkham have for me next.