Some initial impressions of the story cards having now played with them:
Overall the new story effects are much more advantageous for the winner to have happen. With both of the previous story card sets it was less common to see them used for fear that they would provide an opponent an advantage. If you are winning why tamper with success? However, many of the new stories have effects that are auto use for the winner. I would like to highlight a few that sprung up to my attention since we have been using them. If you do not have the Story cards yourself you can check them here: http://www.cardgamedb.com/index.php/CoC/cocdeckbuilder.html (choose, Type: Story, Set: The Shifting Sands).
A New Challenge: This is one of those stories that massively swings the game. I have seen this one change a 1-2 story disadvantage into a 2-2 and I auto win next turn for the player previously behind. Even though I have not seen the following happen yet: if used in the right sequece this story could mean getting a 2nd on the same turn.
Chaos Unleashed: Under the old story card design paradigm this one would work for both players. However, the story effect here only benefits the winner. What this means is, it will be used by any player not relying on a highly specific resource layout. This story essentially creates a 3-4 card draw with no cost and no real downside. Despite not effecting the board the Story is quietly awesome.
The Second Dragon: I owned an opponent by bringing x2 Many-Angled Things into play, causing the helpless slaughter of his characters. There are some great Characters scattered across the factions that create come into play response effects. Use of this card by a deck focused heavy on destruction may mean your opponent gets nothing out of it.
The Seventh Gate: This Story doubles the chances of getting the story of your deck's dreams into play... and it shuffles back into the deck. This one is basically the key to many gates and doubles the possibility of a specific story card effect coming into play. It is one scary story to see on the opening flip!
Worth mentioning is there are now 12 story cards. At any rate, I am hoping this will start a discussion on the strategic implications of story cards on the metagame.