Well this topic hits home when I think about the last season with my players two days ago. The vindicare was again pretty much over the top. The dodge mechanic is broken and I can't believe that this error wasn't obvious during play testing of ascension. I makes me believe that ascension was released in a kind of beta status.
One way to still hit a vindicate which I use is the feint action. It's basically an opposing WS test and if the attacked one fails ( which is not unlikely due to the fact that they don't have that high WS) it loses the ability to dodge or parry the next attack. One that way a vindicare can dodge a storm of bullets from bad ass aliens and imperial elite warriors but fails to avoid being beaten up by an one armed hive scum with a club
Ok... /sarcasm off...., you see my point
For me it is not a satisfying solution of the balancing problem.
The real problem is that temple assasins, primaris psyker and others are far above the power level which is targeted in ascension. (They are more like Dreadnoughts in RoB than normal characters) Ascension should be the beginning level of an party led by an interrogator/inquisitor. Here I believe we should be able to do something on an early Eisenhorn level. It should be a smooth transition from classic acolyte game to an early inquisitor game. Instead it's a radical break in character development and a balancing mess which tries to be too many things at once.
Another problem I encountered with ascension are radical characters and careers. My players have chosen to be a quite radical group of acolytes. We used the Rhb quite frequently and also the interesting career options amongst other things. In ascension there aren't just enough career options for those kind of characters. There seems to be not enough career paths at all if you ask me.