A good way to combine the games together would be to have a story arc where the Achilus Crusade ends, and the crusader forces are recalled back through the warp gate which got them there. It is possible for the Imperium to win, lets say that a victory happens in one front which starts a chain reaction through other fronts which then lead to a victory (or defeat) of imperial forces.
Upon arrival through the warp gate, it would surely come to the attention of some military commanders that the Kronus expanse is virgin territory just waiting to be conquered by the Imperium. The creation of a Koronus Sector might be on the agenda of some leaders, especially those of Calixis sector which see Saint Drusis as wanting them to conquer the expanse anyway. Many Rogue traders would have maped out the area and have a good idea of the planets which inhabit it.
The tone of the war would change. Prior to this, it would be rogue traders acting as conqistadores. Now, the Space Marines and Imperial Guard (and Sisters of Battle) can be brought into the fold. The Storm wardens have their homeworld in the Calixis sector and would naturally see the Expanse as their stomping ground worthy of a crusade (after all, assuming the Achilus Crusade is finished what else are they going to do?). No doubt the Storm Wardens could probably commit a few companies towards the effort, which would be an extremely powerful fighting force.
Rather than the 3 fronts in the Achilus Crusade, there would be about 6 "fronts". 1/ stopping the Ork Waaagh growing, probably the largest front, 2/ skirmishing with the Eldar of Craftworld Kaledor 3/ stopping Rak'Gol expansion 4/ fighting the Styxx, 5/ Fighting the Kroot (which they would have done fighting the Tao anyways 6/ fighting Chaos Reavers
The scale would be different, probably not as intense as it was in the Achilus Crusade. The Orks are disorganized and not the monolithic enemy the Tyrannids are, Eldar break easy, and there seems to be all of 1 Chaos marine leading Chaos forces (as opposed to whole armies of them in the Deathwatch setting). The Deathwatch might even decide to create a small watch station in the Koronus expanse to monitor Xenos activity and further Imperial expansion in to the region.