I'm sure buried down really far is a thread about this but I couldn't find it so I started this one. I'm sure you've had some great combos in your Descent games. Share em!
Zyla with Swift and TK in a RtL game: She's awesome. She zips around the rooms picking up treasure. Every now and then the OL will get a skeleton spawn and skewer her but if she picks up a treasure and a coin spot that would have been left behind (like the Mines mission) then she's done her job.
Landrec with Prodigy: It's very, very common to roll 2 surges with WGBBB. That's blast 2 with the starting rune. That's room clearing power right there. If you can get Inner Fire and/or Vampiric Blood things can get out of hand quickly (I dump three fatigue to upgrade to three silver dice... oh look, Blast 3 +4 damage and I get all my fatigue back... )
Nanok with Bear Tattoo and Enduring: A Starting 5 armor, 18 health character that grapples is easy mode for the heroes.
Brother Glyr Relentless, Able Warrior and Swift: This just came up in our RtL game. An Advance action moves 6 and attacks twice for 1 fatigue (net)... That's pretty nice.
Karnon with Mighty and Cleaving and a Walking Stick: Do the math, it's about 8 damage on average. This one gives Landrec + Prodigy a run for the money in room clearing ability.
What other combos have you guys had that you thought were crazy good. I'd also be interested in train wreck scenarios (One Fist with Weapon Mastery, Ambidextrous and Master Archer or something).