I keep hoping that FFG will expand the TI3 universe into other games. Awhile ago they purchased the mechanics and game engine but not the title or subject rights to the old Dune boardgame, and there was speculation then that it would be turned into a war game within the TI3 universe. A tactical sci-fi combat game, akin to ToI would be great in the TI3 line, as would an LCG and a sci-fi adventure game similar to Runebound, also in the TI3 universe.
The thing is that FFG wholly owns the IP for this universe and it was (and presumably still is) their flagship product. It seems a natural that it should be the basis for a line of different styles of other games expanding upon and exploiting that universe, much as they are doing with the whole Runebound universe with the upcoming deck building game, Runewars, Descent, etc.