In a 5- or 6-team game, if the initial card has two major spawns on the same side, it's possible for one of the blip piles to be empty before the game begins.
If that happens, do you move on - in the strict letter of the rules, this appears to be the case - after the end of Phase 1 of the first turn (so after orders are chosen, but before they're carried out), or should "setup" be treated as a phase in its own right, and so you move on at the end of set up (so before orders for turn 1 are chosen)
If you get an Area 1 location that messes with facings on entering, then it can make quite a big difference!