Possible Spoilers for those who haven't read The Name of the Rose:
I've just started reading my copy of Disciples and I have an overwhelming urge to convert The Name of the Rose to DH with the Eris Transform at the centre of it all. The more I think about it, the more perfect it is. It could be played almost straight up, except this time Jorge is most certainly in the right.
A good setting, a fun plot with lots of puzzles for the PCs to get involved in, a very 40k moral to the story (Forget the promise of progress and understanding. Ignorance is a virtue) and PCs can be involved effortlessly. The real Inquisition showed up to investigate in the book too.
Muahaha.