Jacqueline (Pizza), Jim (Zebra), Zoey (Wings), Bob (Me) vs. Y’Golonac. Innsmouth with Lurker cards.
Every time we were allowed to draw a Unique Item, it was a Tome. Bob got an Encounter to “gain the first Tome” and was forced to roll a Luck Check. Even by ignoring his Rabbit’s Foot, he still had to roll one die for a 6. Jacqueline rolled for successes on a chart, and got the maximum for a Unique Tome. Jim shopped at the General Story, and drew the Ancient Journal. Zoey found a Common Item, and got the King James’ Bible. Thematic, yes, but pounding-head-on-the-table frustrating. 
Bob traded his Dhol Chants to Jacqueline for her Story, which she read for Dr. Herbert West; she used him with her Feeding the Mind to keep her Sanity fresh all game, even into the Final Battle. Bob bought a Tommy Gun, and gave his other weapons to Jim. When he ended up at the Woods for a Clue, he got bushwhacked off to “Endless” Yuggoth. So no Seal and no Trophy.
Zoey went to beat on a Deep One in Innsmouth, but failed the Horror Check. When she stopped off at the Gilman House Hotel, it shipped her off to Y’ha-nthlei, which promptly shipped her off to “Gate with the worst modifier” (R’lyeh). Jim tried to pursue his story, but with all these random Tomes feeding Y’Golonac too fast, there wasn’t time for monster hunting. (No Undead showed up for the whole game anyway.) So he hit the OTHER R’lyeh Gate, but failed to get a chance to offset the horror with his Strange Luck. He ended up on the edge of insanity fighting a Cthonian out there: his Encounter forced him to draw monsters until he got a three-toughness one. They both came out at the same time, in the same neighborhood (Merchant District), and though they both got a Seal, Jim still had to sit on his explored Gate for two turns to achieve it. Jim doesn’t do too well with -3 modifiers.
Innsmouth had left us alone for the most part, but a Gate in Y’ha-nthlei removed every Clue from the board, and dropped enough monsters into vortexes to ruin Jacqueline’s story. Bob was buying Clues with his successful story, but before he was able to score another Seal, a Rumor shot Y’Golonac to 11, and two turns later, Devil Reef finally popped and woke him up. We put up a fairly decent fight—we got him down to 5 Doom Tokens, thanks to Zoey being able to ignore his Resistance—but once he started picking us off, our successes dwindled too much to matter. Jacqueline went down last.
Too many perverse books shut us down too fast; the game was over before we even got to dinner. Y’Golonac made a pretty obnoxious first impression: this group puts him right up there with Glaaki.