From the Dark Heresy timeline pdf:
742.M41 A Pattern Revealed: The Tyrantine Cabal conclusively identifies the “Calixian Pattern Killings” going back at least eleven hundred years.
Do we know anything else about these Pattern Killings? I don't think I've ever come across them in the books. They must be related to Komus or the Tyrantine Cabal would not busy themselves with it. Perhaps it even has ties to the Haarlock mystery?