A thought occured to me that Rogue Trader is very similar in feel to a Western Genre, much like classic movies such as "The good, the Bad, and the Ugly", or more recent mediums like the game Red Dead Redemption. Many of the elements I find similar such as
1/ Very sparce populations: Port Wander is the "Big City" while most folks in Calixis sector have probably never heard of it. It is considered a minor outpost by battlefleet Calixis, and yet this is the major centre of Civilization in the Rogue trader game. Footfall is one step removed from that and has the lawless feel of some of the wilder towns from the American West (Dodge City?), or Mos Aisley from the Star Wars movies. Beyond that it is just "injun territory" and wild wilderness space. Most of the planets described in the main book are dead (and have been so for a long time). Probably the largest human populations are in the Heathen regions and the book describes that as about a billion souls (which, spread over several planets is probably not that much)
2/ Isloation: Most of the Rogue traders are a combination of a covered wagon, carrying their crew across the empty void and there is NOTHING close by. Even some aliens such as the Styix are described as being in "nomadic caravans" in space. Even the planets which have humans in the Heathen regions are described as nomads with very few stable cities.
3/ Lawlessness. Even in Port Wander, there is a miniscule Arbite presence (the Law) and a fairly large criminal element. It goes downhill fast as soon as you leave and enter Footfall, and after that the law is only the vast wilderness. Rogue traders are advised to carry a big gun and bring their version of Imperial rule to any areas that they settle since the rule of the Imperium has absolutely no reach there.
4/ Opportunism: It occured to me that a good Rogue Trader would have been Daniel Plainfield from the movie There will be Blood (played by Daniel Day Lewis). An absolutely ruthless bastard who will pull every resource out of a planet and crush anyone who stands in his way. No doubt the amount of competition between Rogue Traders is legendary and that their Greed knows no bounds. Similar to the Robber Barons of the Old west who built massive empires on the backs of cheap labour.
That is the beautiy of the game. Rather than being in the centre of the Imperium, it is on the edge of space in a totally forsaken region. There is something facinating about being in a very isolated part of the world with only scattered pockets of humanity. Individuals count for more rather than being another face in the crowd. Things are simpler, yet the challenges are larger because of the sense of being alone and no one is coming to help. Civilization is pushing itself out. The Western era has a very interesting appeal.