How many people are actually playing it? What do you think? I like the high level "intrigue" type game, but it seems that it always comes down to another way to make a combat monster...what do you think?

How much the GM may play up the intrigue and politics of being at that level sets the tone. Ascension characters should be a right terror, it's the internal politics of the Inquisition that becomes the best leash for them. Congratulations, your character is an electrified god of an Inquisitor! Condolences, all those different factions are now have their eyes on you. Welcome to a game where your skill with a bolter may not help you and shooting the wrong person could put you on the run.

No problems beyond what you encounter in any gaming environment so far. Granted my current group ranges from rank 9 to rank 6, so none of them are exactly "godlike" yet. No Vindicares (The broken dodges forever crap and zero social capacity will NOT be missed!) but we do have a soon-to-be Primaris Psyker. Guardsman Officer/Inquisitor, Techpriest/Magos and Assassin/Gun Saint are the ascended ones so far. Guardsman assault/Stormtrooper, Templar Calixis/Primaris Psyker, Adept/Sage, Cleric/ ?? and Arbitrator/ ?? are waiting in the wings.

If you can manage and handle Rogue Trader it is really no more or less overkill than that.