Played my first game of Rogue Trader and noticed something right off the bat with explorator implants. Many of them, specifically the Logis Implant give some +10% bonus when activated, but you take a Toughness test to see if you take a level of fatigue.
The only problem with this is that as soon as you take 1 level of fatigue, you are considered Fatigued and all tests are at -10% penalties.
With how low toughness can be even for mid level players, statistically there's almost no point to trying to use this, since you're most likely going to either negate your bonus from the Logis Implant and make all other tests more difficult, or even worse, fail the implant use test, and fail the toughness and end up much worse than you started.