I suppose this my vary by difficulty, but let's talk about standard. When would you try an "optional" test (such as investigating for clues or location test to pass a story or even attempt to fight/evade) or just do something else (such as move to a location or draw a card or gain a resource). Would you attempt if you had a zero difference with the skill involved? +1? +2? When is it okay to risk a low difference check?
Edit: I feel The Circle Undone need a mention as haunted really makes "trying" not really a good option as failure has huge costs. You have to be in it to win it.
Edited by Hordeoverseer