I've played a fair amount of 2.0 so far, and I'm starting to notice that against similarly skilled players to me that my most crucial decisions happen on turn 0. When I go back and post-mortem the game, especially when I lose, I'm able to pick out things that had I done them in setup it would have dramatically altered the way the game played out. Just yesterday I played two games, same lists both games. I won the first one pretty decisively and the second I lost by a decent margin. The second game I had finished setup and was placing my dials when I realized that I had made a major error in where I placed Whisper, and in the end my opponent was able to capitalize on that and box her in.
I wouldn't say that I'm worried about it from a game health perspective, but I'm wondering if other people are seeing similar things in their games where Turn 0 plays a major role in the outcome.