Well how 'bout a Warhammer 40K Dune?
I am not familiar with the Twilight Imperium universe; however, when FFG made the announcement for a
rethemed Dune, I'm guessing the GW licence agreement was not yet finalized (or maybe even pursued).
In light of recent developments, such as the excellent Chaos in the Old World boardgame, I think a rethemed
Dune can have real possibilities in the rich 40k universe where it's crawling with fully fledged factions with strong identities & strengths/weaknesses.
It would be a more warmongering game than an economic game (you can tell that I haven't played Dune), but I'd be fine with it if Mr. Lang helmed the design.