This just happened in one of my games, and my opponent just got up and left.

On a previous turn, the opponent had played Control the Weak, the action card that lets you choose your opponent's house for the next turn. On my turn (and this was only like turn 3 or something), I played Witch of the Eye and Mimicry to copy Control the Weak from his discard pile. I got lucky and picked a house that he had no cards in his hand for and no creatures on the board. He had to end his turn. Then, I reaped with Witch of the Eye, picked up Mimicry from my discard and played it as a copy of Control the Weak again. Rinse and repeat. The opponent could never draw new cards because he couldn't play or discard any. I could reap once every turn and he was totally locked out.