In the case that I have two Alchemist's Guild Halls in play, and play a card out of Shadows, may I kneel an Alchemist's Guild Hall to kneel a target, and then, in response to the same creature coming from shadows, kneel my second Guild Hall to kneel a second character?

Also, may I use Alchemist's Guild Hall's Response in response to itself being revealed? I mean, when I reveal an Alchemist's Guild Hall from the Shadows, my I kneel it to kneel another character or location right out?

The answer to all of your questions are, "Yes."

my response to that is, "very cool"

Hodor!