My two cents.
if I was playing a game where random encounters for a big feature like a hex crawl I would do t like this.
how dangerous is the area 1-5
how actively hunting for travelers are those threats 1-5
I’d have the region roll against the pcs using the pool above against probably a group survival check opposed roll.
I would then interpret the roll with roughly along the following lines
If the enviornemt wins an encounter happens with a rough difficulty based on successes. Off the top of my head a rival per success and minion per advantage with despair being a regional big bad.
That’s my 2 minute napkin math solution. You have now made me want to try this so I’ll report back.